The objective of this article is to present a proposal (working paper) for a quantitative analysis tool to help technology transfer offices (TTOs) improve their structures, processes and procedures. Our research started from the study of internal practices and structures that facilitate the interaction between R&D institutions, their TTOs and regional surroundings. We wanted to identify “bottlenecks” in those processes, procedures, and structures. We mapped the bottlenecks in a set of “facilitators” collected from observed best practices in select European and North American R&D institutions. One of the most important aspects of our research is the use of facilitators and rules integrated in a management framework called “Master Plan to Transfer Technology”. This is a compilation of 271 rules referring to 43 facilitators distributed in seven groups that explain the actual best practices inside (and around) a TTO. The facilitators and rules are the output of the coding process step in grounded theory, where facilitators are the categories and rules are their properties. The BTP (Best Transfer Practices) output is the Analysis and Recommendations Report. It shows the possible necessary process reengineering and other recommendations capable of optimizing/improving the most important processes, procedures and structures. The scientific domain of this research is the management of innovation, knowledge and technology transfer. The central subject is the relationships between companies and the innovation agents concerned with technology transfer. We developed a quantitative tool to assess and study those agents as knowledge disseminators. We recommend ways to maximize effectiveness when trying to take care of the company objectives, such as technology transfer and valorisation of knowledge. The BTP tool is based on a teamwork approach and system automation. The research methodology is based on document analysis, participative observation and interviews with key actors from 29 TTOs in the US and five in Portugal . All of these collected data gave us the possibility to lead research on grounded theory, aiming a theoretical framework we call Master Plan to TT and one assessment tool based on it. The BTP tool resulted from a tested analysis tool for ICT systems in hospitals (Best Hospital Practices - BHP), which resulted from the Best Enterprise Practices – BES [BHP10]. Thirty-five small and medium enterprises (SMEs) empirically tested and validated the BES and five hospitals empirically tested and validated the BHP. The results provided a basis to implement in TT management. Our set of facilitators (that is based on the best actual practices in TT) came from a previous study carried out in Portugal and the US. The study included validation [RES09] from 28 interviews and a survey with 24 actors in TT processes in Portugal and 18 interviews and a survey with 34 actors in TT processes in the US.