<jats:p>Addressing sustainable development and societal challenges have been placed at the heart of all government priorities, detachedly of country stage of development, as a mean to achieve prosperity through social cohesion and equality. In this setting, entrepreneurship appears to be a powerful tool to encompass economic, social, and environmental goals, particularly when sustainability oriented. Sustainability oriented entrepreneurs (henceforth SEO) are still focused in profit maximization strategies combined with environmental respect and social inclusion and rely on a firm-based entrepreneurship initiative integrating the triple bottom line. The chapter aims to understand the role of culture (culture and social norms) on SEO activity among several countries, along with gender heterogeneity. Specifically, the study determines the moderating effect of (national) culture on SEO. The study uses a logistic regression and the Global Entrepreneurship Monitor (GEM) database from 2015, with information of 60 countries. </jats:p>