In order to better manage knowledge for making it become productive and unlocking its developmental potential a comprehensive set of concepts, methods and tools is required that helps companies in purposefully intervening in their core processes. Challenges mainly consist in the wide and ever growing variety of those supportive means, missing guidance in selecting appropriate methods and tools, the need for adapting theoretical concepts to a certain company environment while implementation, requirements for predicting efforts and impact from knowledge-related interventions. Therefore, the paper introduces and elaborates the concept of a "knowledge clinic" that is meant to support companies in their knowledge investments in the same way as any process of medical treatment with the human body is organized: diagnosis, healing, cross-checking. In particular the paper motivates the approach, discusses its theoretical background, explains its structure and way of working, and derives conclusions on implications on change processes at company and economy levels. With this the paper wants to contribute to step forward on the road to support organizations in dealing with and profiting from knowledge.