The paper presents the methodological framework for unlocking developmental potential of knowledge in order to support decision makers at company level. Key elements are (i) results and findings from an ongoing knowledge management impact study; (ii) an approach for benchmarking a company's knowledge management maturity and proposing a pathway to effectively and efficiently improve the level of maturity; and (iii) a sensitivity model for evaluating knowledge management interventions according to their effectiveness and directly controlling those change processes. The proposed methodological framework aims to help companies in identifying their needs for change and purposefully intervening in their processes and eventually to lend them a hand in managing their human resources, selecting technology or changing the organisation. For this, elements are to be integrated into a web-based infrastructure in order to give company managers direct support and a test bed for defining the most appropriate intervention strategy. Whereas this is the front-end for accessing any methodological support, the paper focuses on the conceptual basis of the three key elements and the theoretical basis for enabling knowledge-based company development.